In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor.

@article{Jeang1993InVA,
  title={In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor.},
  author={K T Jeang and Raymond Y. T. Chun and Nan Horng Lin and Anne Gatignol and Charles G. Glabe and Hung Fan},
  journal={Journal of virology},
  year={1993},
  volume={67 10},
  pages={
          6224-33
        }
}
Recent genetic experiments have suggested that tat transactivation of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat requires functional upstream enhancer sequences--Sp1 sites, in particular. In these experiments, HeLa cell nuclear extracts were passed over affinity matrices containing chemically synthesized or bacterially expressed HIV-1 Tat. Assay of material that bound to and eluted from the Tat matrices revealed the presence of the Sp1 transcription factor. Other… CONTINUE READING

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