In vitro and in vivo availability of hydrophilized phenytoin from capsules.

Abstract

The effect of phenytoin hydrophilization on the liquid penetration rate into prepared plugs, on the disintegration time, on the in vitro release rate, and on in vivo absorption in humans was studied. Hydrophilization was performed by intensive mixing of the hydrophobic drug with a small amount of methylcellulose solution. Liquid penetration into the treated… (More)

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@article{Lerk1979InVA, title={In vitro and in vivo availability of hydrophilized phenytoin from capsules.}, author={Coenraad F. Lerk and M. Lagas and Loraine Lie-A-Huen and P Broersma and Klaas Zuurman}, journal={Journal of pharmaceutical sciences}, year={1979}, volume={68 5}, pages={634-8} }