In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna.

@article{Cutler2012InVA,
  title={In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna.},
  author={Murray J. Cutler and Bradley L. Urquhart and Thomas J. Velenosi and H E Meyer zu Schwabedissen and George K. Dresser and Brenda F. Leake and Rommel G. Tirona and Richard B Kim and David J. Freeman},
  journal={Journal of clinical pharmacology},
  year={2012},
  volume={52 4},
  pages={
          530-42
        }
}
Mesna and its dimer, dimesna, are coadministered for mitigation of ifosfamide- and cisplatin-induced toxicities, respectively. Dimesna is selectively reduced to mesna in the kidney, producing its protective effects. In vitro screens of uptake and efflux transporters revealed saturable uptake by renal organic anion transporters OAT1, OAT3, and OAT4. Efflux transporters breast cancer resistance protein; multidrug and toxin extrusion 1 (MATE1); multidrug resistance proteins MRP1, MRP2, MRP4, and… CONTINUE READING

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