In vitro and in vivo antitumor effects of folate-targeted ursolic acid stealth liposome.

  title={In vitro and in vivo antitumor effects of folate-targeted ursolic acid stealth liposome.},
  author={Guang Yang and Tan Yang and Wendian Zhang and Miao Miao Lu and Xiang Ma and Guangya Xiang},
  journal={Journal of agricultural and food chemistry},
  volume={62 10},
The antitumor efficacy of ursolic acid (UA) was limited by poor hydrophilicity and low bioavailability. To overcome this issue, UA was encapsulated in liposomes modified with folate conjugates for better solubility and bioavailability. This novel agent was prepared by a thin-film dispersion method and characterized by mean diameter, zeta potential, and entrapment efficiency (160.1 nm, -21.2 mV, and 88.9%, respectively). In vitro, cellular uptake efficiency, cytotoxicity, apoptosis, and cell… CONTINUE READING
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