In vitro and in vivo antitumor effects of bisphosphonates.

  title={In vitro and in vivo antitumor effects of bisphosphonates.},
  author={Philippe Cl{\'e}zardin and Pierrick Fournier and Sandrine Boissier and Olivier Peyruchaud},
  journal={Current medicinal chemistry},
  volume={10 2},
Bisphosphonates are powerful inhibitors of osteoclast-mediated bone resorption. They are currently used in the palliative treatment of bone metastases. However, bisphosphonates do not only act on osteoclasts. There is now extensive in vitro preclinical evidence that bisphosphonates can act on tumor cells: they inhibit tumor cell adhesion to mineralized bone as well as tumor cell invasion and proliferation. Bisphosphonates induce also tumor cell apoptosis and stimulate gammadelta T cell… CONTINUE READING

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