In vitro and in vivo antitumor effects of 50 to 100-KDa components from B16 melanoma culture supernatant.

@article{Qin2015InVA,
  title={In vitro and in vivo antitumor effects of 50 to 100-KDa components from B16 melanoma culture supernatant.},
  author={Ying-song Qin and Xiaoqian Zhang and Xiangyu Zhang},
  journal={Oncology letters},
  year={2015},
  volume={10 1},
  pages={
          149-155
        }
}
The development of immunological therapies for melanoma has been of considerable concern in recent years. Whole tumor cell lysates have been used to develop antitumor vaccines, but the effective components of the lysates have not been identified. In the present study, protein elements were purified from the B16 supernatant to analyze the in vitro chemotaxis towards mouse spleen lymphocytes using a Boyden chamber. Prior to establishing a B16 melanoma model, C57BL/6 mice were vaccinated with… CONTINUE READING

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