In vitro and in vivo antimalarial activity of amphiphilic naphthothiazolium salts with amine-bearing side chains.

@article{Ulrich2014InVA,
  title={In vitro and in vivo antimalarial activity of amphiphilic naphthothiazolium salts with amine-bearing side chains.},
  author={P. Ulrich and Gregory R. Gipson and M. Clark and A. Tripathi and D. Sullivan and C. Cerami},
  journal={The American journal of tropical medicine and hygiene},
  year={2014},
  volume={91 4},
  pages={
          824-32
        }
}
Because of emerging resistance to existing drugs, new chemical classes of antimalarial drugs are urgently needed. We have rationally designed a library of compounds that were predicted to accumulate in the digestive vacuole and then decrystallize hemozoin by breaking the iron carboxylate bond in hemozoin. We report the synthesis of 16 naphthothiazolium salts with amine-bearing side chains and their activities against the erythrocytic stage of Plasmodium falciparum in vitro. KSWI-855, the… Expand
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