In vitro and in vivo antifungal activities of D0870, a new triazole agent.

@article{Yamada1993InVA,
  title={In vitro and in vivo antifungal activities of D0870, a new triazole agent.},
  author={Haruyasu Yamada and T Tsuda and Takashi Watanabe and Masataka Ohashi and Kenji Murakami and Hiroshi Mochizuki},
  journal={Antimicrobial agents and chemotherapy},
  year={1993},
  volume={37 11},
  pages={2412-7}
}
In vitro and in vivo antifungal activities of D0870 were evaluated in comparison with those of fluconazole. D0870, which is the R-enantiomer of ICI195,739, was found to be the mycologically active enantiomer by comparing the activities of D0870 with those of M16355 (S-enantiomer of ICI195,739). D0870 showed a broad spectrum of antifungal activity and MICs and minimum antibiotic concentrations 4- to 2,000-fold lower in synthetic amino acid medium (fungal) agar than those of fluconazole for… CONTINUE READING

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