In vitro and in vivo antibacterial activities of FK037, a novel parenteral broad-spectrum cephalosporin.

@article{Fu1993InVA,
  title={In vitro and in vivo antibacterial activities of FK037, a novel parenteral broad-spectrum cephalosporin.},
  author={K P Fu and Barbara D Foleno and S C Lafredo and John M Lococo and D. Isaacson},
  journal={Antimicrobial agents and chemotherapy},
  year={1993},
  volume={37 2},
  pages={301-7}
}
FK037, a new parenteral cephalosporin, is an oxime-type cephem antibiotic with a 1-hydroxyethyl-5-amino-pyrazole moiety at the 3 position. FK037 was evaluated for antimicrobial activity in vitro and in vivo. In vitro, FK037 was twofold or more active than ceftazidime, cefoperazone, cefotaxime, and ceftriaxone against Pseudomonas aeruginosa (MIC for 90% of the strains [MIC90] = 32 micrograms/ml), members of the family Enterobacteriaceae (MIC90 < or = 2 micrograms/ml), group A streptococci (MIC90… CONTINUE READING
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