In vitro and in vivo antiarrhythmic effects of prazosin in the rat.


The possible antiarrhythmic action of prazosin was studied on two experimental models: a focus of ectopic automaticity in the rat isolated right ventricle and arrhythmias induced by i.v. CaCl2 in anaesthetized animals. In vitro, prazosin at 10(-5)M abolished the ectopic automaticity focus in 83% of cases (10/12). The effects of prazosin were not modified by… (More)


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