In vitro and in vivo anti-leukemic effects of cladoloside C2 are mediated by activation of Fas/ceramide synthase 6/p38 kinase/c-Jun NH2-terminal kinase/caspase-8

@inproceedings{Yun2018InVA,
  title={In vitro and in vivo anti-leukemic effects of cladoloside C2 are mediated by activation of Fas/ceramide synthase 6/p38 kinase/c-Jun NH2-terminal kinase/caspase-8},
  author={Seong-Hoon Yun and Eun-Hye Sim and Sang-Heum Han and Tae-Rang Kim and Mi-Ha Ju and Jin Yeong Han and Jin-sook Jeong and Sung-Hyun Kim and Alexandra S. Silchenko and Valentin A Stonik and Joo-In Park},
  booktitle={Oncotarget},
  year={2018}
}
We previously demonstrated that the quinovose-containing hexaoside stichoposide C (STC) is a more potent anti-leukemic agent than the glucose-containing stichoposide D (STD), and that these substances have different molecular mechanisms of action. In the present study, we investigated the novel marine triterpene glycoside cladoloside C2 from Cladolabes… CONTINUE READING