In vitro and in vivo anti-inflammatory activity of the new glucocorticoid ciclesonide.

@article{Stoeck2004InVA,
  title={In vitro and in vivo anti-inflammatory activity of the new glucocorticoid ciclesonide.},
  author={Michael Stoeck and Richard Riedel and Guenther Hochhaus and Dietrich H{\"a}fner and Jose Felix Marti Masso and Beate Schmidt and Armin Hatzelmann and Degenhard Marx and Daniela S. Bundschuh},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={309 1},
  pages={249-58}
}
The glucocorticoid ciclesonide is the 2'R-epimer of 2'-cyclohexyl-11beta-hydroxy-21-isobutyryloxy-16bH-dioxolo[5',4':16,17]pregna-1,4-diene-3,20-dione. The active metabolite desisobutyryl-ciclesonide (des-CIC) is derived from ciclesonide by esterase cleavage of isobutyrate at the C21 position. The relative binding affinities at the rat glucocorticoid receptor were dexamethasone, 100; ciclesonide, 12; des-CIC, 1212; and budesonide, 905. Des-CIC potently inhibited the activation of murine and… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 37 references

Ciclesonide, a novel ‘on-site activated’ inhaled corticosteroid with potent anti-inflammatory activity

  • MG Belvisi, DS Bundschuh, +6 authors ML Foster
  • J Allergy Clin Immunol 109:A59
  • 2002
Highly Influential
1 Excerpt

Esterases involved in the hydrolysis of ciclesonide in human tissues

  • E Mutch, R Nave, K Zech, FM Williams
  • Eur Respir J 22 (Suppl 45):P1749
  • 2003
1 Excerpt

Pharmacokinetics of 14 Cciclesonide after oral and intravenous administration in healthy subjects

  • R Nave, TD Bethke, SP vanMarle, K Zech
  • Eur Respir J
  • 2002
1 Excerpt

Ciclesonide

  • NE Mealy, M Bayes, J Castaner
  • Drugs Future
  • 2001
2 Excerpts

Ciclesonide. Drugs Future 26:1033–1039

  • NE Mealy, M Bayes, J Castaner
  • 2001
2 Excerpts

In vitro anti-inflammatory activity of the new glucocorticoid ciclesonide in human cells (Abstract)

  • M Stoeck, A Hatzelmann, MG Belvisi, ML Foster, DS Bundschuh
  • Eur Respir J 18 (Suppl 33):P679
  • 2001
2 Excerpts

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