In vitro and in vivo analysis of the mechanism of absorption enhancement by palmitoylcarnitine.

@article{Hochman1994InVA,
  title={In vitro and in vivo analysis of the mechanism of absorption enhancement by palmitoylcarnitine.},
  author={Jerome H. Hochman and Joseph A. Fix and Edward L. Lecluyse},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1994},
  volume={269 2},
  pages={813-22}
}
Long-chain acylcarnitines (12-18 carbon fatty acid esters) dramatically enhance the absorption of hydrophilic drugs across intestinal mucosa without altering the morphology of the epithelium. The mechanism underlying these effects was studied using the colon carcinoma cell line Caco-2. Caco-2 monolayers treated with 0.2 mM palmitoylcarnitine (PCC) show dramatic increases in the transport of hydrophilic markers. This enhanced transport coincides with a rapid drop in transepithelial electrical… CONTINUE READING
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