In vitro and in vivo activity of major constituents from Pluchea carolinensis against Leishmania amazonensis

@article{Montrieux2014InVA,
  title={In vitro and in vivo activity of major constituents from Pluchea carolinensis against Leishmania amazonensis},
  author={Elly Montrieux and Wilmer H Perera and Marley Garc{\'i}a and Louis Maes and P. Merino de Cos and Lianet Monzote},
  journal={Parasitology Research},
  year={2014},
  volume={113},
  pages={2925-2932}
}
The search for new therapeutic agents from natural sources has been a constant for the treatment of diseases such as leishmaniasis. Herein, in vitro and in vivo pharmacological activities of pure major phenolic constituents (caffeic acid, chlorogenic acid, ferulic acid, quercetin, and rosmarinic acid) from Pluchea carolinensis against Leishmania amazonensis are presented. Pure compounds showed inhibitory activity against promastigotes (IC50 = 0.2–0.9 μg/mL) and intracellular amastigotes (IC50… CONTINUE READING