In vitro and in vivo activity of Aloe vera leaf exudate in experimental visceral leishmaniasis

  title={In vitro and in vivo activity of Aloe vera leaf exudate in experimental visceral leishmaniasis},
  author={Avijit Dutta and D. Sarkar and A. Gurib-Fakim and C. Mandal and M. Chatterjee},
  journal={Parasitology Research},
The leishmanicidal activity of Aloe vera leaf exudate (AVL) has been demonstrated in promastigotes and axenic amastigotes, but its effectiveness in animal models has not been evaluated. The presence of alkaloids, triterpenes, cyanidines, proanthocyanidines, tannins, and saponins in AVL was identified. Its effectiveness in four Leishmania donovani strains was studied both in promastigotes (IC50 ranged from 70–115 μg/ml) and amastigotes (IC50 ranged from 3.1–11.4 μg/ml). In amastigotes, the… Expand
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