In vitro and in vivo activities of a new cephalosporin, FR264205, against Pseudomonas aeruginosa.

@article{Takeda2007InVA,
  title={In vitro and in vivo activities of a new cephalosporin, FR264205, against Pseudomonas aeruginosa.},
  author={Shinobu Takeda and Toru Nakai and Yoshimi Wakai and Fumiaki Ikeda and Kazuo Hatano},
  journal={Antimicrobial agents and chemotherapy},
  year={2007},
  volume={51 3},
  pages={826-30}
}
FR264205 is a novel parenteral 3'-aminopyrazolium cephalosporin. This study evaluated the in vitro and in vivo activities of FR264205 against Pseudomonas aeruginosa. The MIC of FR264205 at which 90% of 193 clinical isolates of P. aeruginosa were inhibited was 1 microg/ml, 8- to 16-fold lower than those of ceftazidime (CAZ), imipenem (IPM), and ciprofloxacin (CIP). FR264205 also exhibited this level of activity against CAZ-, IPM-, and CIP-resistant P. aeruginosa. The reduction in the… CONTINUE READING

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