In vitro and in vivo activities of Sch 39304, fluconazole, and amphotericin B against Histoplasma capsulatum.

@article{Kobayashi1990InVA,
  title={In vitro and in vivo activities of Sch 39304, fluconazole, and amphotericin B against Histoplasma capsulatum.},
  author={George S. Kobayashi and Simon J. Travis and Mar{\'i}a Guadalupe Rinaldi and Gerald Medoff},
  journal={Antimicrobial agents and chemotherapy},
  year={1990},
  volume={34 4},
  pages={
          524-8
        }
}
The antifungal activities of amphotericin B and two triazoles, Sch 39304 and fluconazole, were tested against Histoplasma capsulatum. In this study Sch 39304 compared favorably with amphotericin B in treating histoplasmosis in normal and leukopenic mice, whereas fluconazole was much less active. The differences in the efficacies of the triazoles appeared to be due to differences in their pharmacokinetics and the dosage schedule that was used. For amphotericin B there was a good correlation… CONTINUE READING

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SHOWING 1-10 OF 26 REFERENCES

Azole antifungal agents: emphasis on new triazoles.

  • Antimicrobial agents and chemotherapy
  • 1988
VIEW 2 EXCERPTS

Comparative in vitro activity of LY121019 and amphotericin B against clinical isolates of Candida species.

  • European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
  • 1988
VIEW 1 EXCERPT

Antifungal susceptibility tests.

  • Antimicrobial agents and chemotherapy
  • 1987
VIEW 1 EXCERPT

Cryptococcal meningitis and fluconazole.

  • Annals of internal medicine
  • 1987
VIEW 1 EXCERPT