In vitro and ex vivo inhibitory effects of L- and D-enantiomers of NG-nitro-arginine on endothelium-dependent relaxation of rat aorta.

@article{Wang1993InVA,
  title={In vitro and ex vivo inhibitory effects of L- and D-enantiomers of NG-nitro-arginine on endothelium-dependent relaxation of rat aorta.},
  author={Y X Wang and Christine Poon and Catherine Cheuk Ying Pang},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={265 1},
  pages={112-9}
}
The in vitro and ex vivo inhibitory effects of NG-nitro-L-arginine (L-NNA) and NG-nitro-D-arginine (D-NNA) on endothelium-dependent relaxations were studied in rat aortic rings. L-NNA (3 x 10(-7) to 3 x 10(-5) M) but not D-NNA (3 x 10(-6) to 3 x 10(-4) M) induced contraction of resting aortic rings and potentiated phenylephrine-induced contraction in a concentration-dependent manner. In phenylephrine-preconstricted aortic rings, L-NNA (3 x 10(-7) to 3 x 10(-5) M) and D-NNA (3 x 10(-6) to 3 x 10… CONTINUE READING