In vitro and clinical correlates of mefloquine resistance of Plasmodium falciparum in eastern Thailand.

@article{Childs1991InVA,
  title={In vitro and clinical correlates of mefloquine resistance of Plasmodium falciparum in eastern Thailand.},
  author={Gregg E. Childs and E F Bourdeau and T Wimonwattratee and L Pang and Wilbur K. Milhous},
  journal={The American journal of tropical medicine and hygiene},
  year={1991},
  volume={44 5},
  pages={
          553-9
        }
}
A series of isolates of Plasmodium falciparum from eastern Thailand was collected prior to and after treatment failure with mefloquine. Patterns of drug sensitivity to standard and new antimalarials were characterized by using an in vitro assay based on the inhibition of schizont maturation. In vitro levels of mefloquine sensitivity of isolates were correlated with clinical treatment failures. In vitro parasite resistance to mefloquine is defined as an inhibitory dose-50 value greater than 20… CONTINUE READING

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