In vitro and In vivo Radiosensitization Induced by the DNA

  • Methylating AgentTemozolomide, WhoonJong Kil, +5 authors Kevin Camphausen
  • Published 2008


Purpose:Temozolomide, a DNAmethylating agent, is currently undergoing clinical evaluation for cancer therapy. Because temozolomidehas been shown to increase survival rates of patientswith malignant gliomas when given combined with radiation, and there is conflicting preclinical data concerning the radiosensitizing effects of temozolomide, we further… (More)


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