In vitro analysis of the binding of ADAR2 to the pre-mRNA encoding the GluR-B R/G site.

@article{Ohman2000InVA,
  title={In vitro analysis of the binding of ADAR2 to the pre-mRNA encoding the GluR-B R/G site.},
  author={Marie Wall{\'e}n Ohman and Annika M K{\"a}llman and Brenda L Bass},
  journal={RNA},
  year={2000},
  volume={6 5},
  pages={687-97}
}
The ADAR family of RNA-editing enzymes deaminates adenosines within RNA that is completely or largely double stranded. In mammals, most of the characterized substrates encode receptors involved in neurotransmission, and these substrates are thought to be targeted by the mammalian enzymes ADAR1 and ADAR2. Although some ADAR substrates are deaminated very promiscuously, mammalian glutamate receptor B (gluR-B) pre-mRNA is deaminated at a few specific adenosines. Like most double-stranded RNA… CONTINUE READING