In vitro analysis of the Staphylococcus aureus lipoteichoic acid synthase enzyme using fluorescently labeled lipids.

@article{KaratsaDodgson2010InVA,
  title={In vitro analysis of the Staphylococcus aureus lipoteichoic acid synthase enzyme using fluorescently labeled lipids.},
  author={Maria Karatsa-Dodgson and Mirka E W{\"o}rmann and Angelika Gr{\"u}ndling},
  journal={Journal of bacteriology},
  year={2010},
  volume={192 20},
  pages={5341-9}
}
Lipoteichoic acid (LTA) is an important cell wall component of Gram-positive bacteria. The key enzyme responsible for polyglycerolphosphate lipoteichoic acid synthesis in the Gram-positive pathogen Staphylococcus aureus is the membrane-embedded lipoteichoic acid synthase enzyme, LtaS. It is presumed that LtaS hydrolyzes the glycerolphosphate head group of the membrane lipid phosphatidylglycerol (PG) and catalyzes the formation of the polyglycerolphosphate LTA backbone chain. Here we describe an… CONTINUE READING
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