In vitro analysis of rod composition and actin dynamics in inherited myopathies.

@article{Vandebrouck2010InVA,
  title={In vitro analysis of rod composition and actin dynamics in inherited myopathies.},
  author={Aur{\'e}lie Vandebrouck and Ana Domazetovska and Nancy Mokbel and Sandra T Cooper and Biljana Ilkovski and Kathryn N North},
  journal={Journal of neuropathology and experimental neurology},
  year={2010},
  volume={69 5},
  pages={429-41}
}
Rods are the pathological hallmark of nemaline myopathy, but they can also occur as a secondary phenomenon in other disorders, including mitochondrial myopathies such as complex I deficiency. The mechanisms of rod formation are not well understood, particularly when rods occur in diverse disorders with very different structural and metabolic defects. We compared the characteristics of rods associated with abnormalities in structural components of skeletal muscle thin filament (3 mutations in… CONTINUE READING