In vitro analysis of expression vectors for DNA vaccination of horses: the effect of a Kozak sequence

@article{lafsdttir2008InVA,
  title={In vitro analysis of expression vectors for DNA vaccination of horses: the effect of a Kozak sequence},
  author={Guðbj{\"o}rg {\'A}sta {\'O}lafsd{\'o}ttir and Vilhj{\'a}lmur Svansson and Sigurður Ingvarsson and Eliane Marti and Sigurbj{\"o}rg Torsteinsd{\'o}ttir},
  journal={Acta Veterinaria Scandinavica},
  year={2008},
  volume={50},
  pages={44 - 44}
}
One of the prerequisite for developing DNA vaccines for horses are vectors that are efficiently expressed in horse cells. We have analysed the ectopic expression of the human serum albumin gene in primary horse cells from different tissues. The vectors used are of pcDNA and pUC origin and include the cytomegalovirus (CMV) promoter. The pUC vectors contain CMV intron A whereas the pcDNA vectors do not. Insertion of intron A diminished the expression from the pcDNA vectors whereas insertion of a… CONTINUE READING

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