In vitro analysis of PDZ-dependent CFTR macromolecular signaling complexes.

@article{Wu2012InVA,
  title={In vitro analysis of PDZ-dependent CFTR macromolecular signaling complexes.},
  author={Yanning Wu and Shuo Ning Wang and Chunying Li},
  journal={Journal of visualized experiments : JoVE},
  year={2012},
  volume={66}
}
Cystic fibrosis transmembrane conductance regulator (CFTR), a chloride channel located primarily at the apical membranes of epithelial cells, plays a crucial role in transepithelial fluid homeostasis(1-3). CFTR has been implicated in two major diseases: cystic fibrosis (CF)(4) and secretory diarrhea(5). In CF, the synthesis or functional activity of the… CONTINUE READING