In vitro amplification of prions from milk in the detection of subclinical infections.

@article{Gough2009InVA,
  title={In vitro amplification of prions from milk in the detection of subclinical infections.},
  author={Kevin Christopher Gough and Claire A. Baker and Maged Mohamed Taema and Ben Charles Maddison},
  journal={Prion},
  year={2009},
  volume={3 4},
  pages={236-9}
}
Prions can be amplified by serial protein misfolding cyclic amplification (sPMCA) from the milk of a high proportion of apparently healthy, scrapie exposed sheep with PRNP genotypes not previously associated with high disease penetrance. These data strongly suggest the widespread presence of subclinical scrapie infections within scrapie-exposed flocks containing sheep with a range of susceptible PRNP genotypes. These data also lead to the hypothesis that similar subclinical disease states may… CONTINUE READING

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