In vitro alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists.

@article{Williams1999InVA,
  title={In vitro alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists.},
  author={Timothy J. Williams and Daniel Blue and Don V Daniels and Bruce Davis and Todd R Elworthy and Joel Robert Gever and M S Kava and David Morgans and Fernando Padilla and Shlomit Tassa and R L Vimont and Christopher R Chapple and Russell Chess-Williams and R. M. Eglen and David E Clarke and Anthony P. D. W. Ford},
  journal={British journal of pharmacology},
  year={1999},
  volume={127 1},
  pages={252-8}
}
It has been hypothesized that in patients with benign prostatic hyperplasia, selective antagonism of the alpha1A-adrenoceptor-mediated contraction of lower urinary tract tissues may, via a selective relief of outlet obstruction, lead to an improvement in symptoms. The present study describes the alpha1-adrenoceptor (alpha1-AR) subtype selectivities of two novel alpha1-AR antagonists, Ro 70-0004 (aka RS-100975) and a structurally-related compound RS-100329, and compares them with those of… CONTINUE READING

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