In vitro affinity reduction of biologic response modifiers from production buffy coat platelets exposed to recombinant protein receptors.


BACKGROUND Recent studies link biologic response modifiers found in donor platelet (PLT) concentrates to transfusion reactions. We tested a novel method to deplete BRMs from PLT concentrates using apheresis. STUDY DESIGN AND METHODS Whole blood from 25 donors was treated to yield PLTs for in vitro measurements on Days 2, 5, and 7. On Day 7, PLTs were… (More)
DOI: 10.1111/trf.13051