In vitro acute and prolonged effects of melatonin on purified rat Leydig cell steroidogenesis and adenosine 3',5'-monophosphate production.

Abstract

The effects of melatonin (MLT; 4.3 pM to 4.3 microM) on rat Leydig cell steroidogenesis and cAMP production were investigated during 3-h LH (30 mIU/ml) stimulation. Having noted a dose-dependent inhibition of testosterone (T) release, we also tested MLT in the presence of the cAMP activator forskolin (1 microM), the phosphodiesterase inhibitor… (More)

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@article{Valenti1995InVA, title={In vitro acute and prolonged effects of melatonin on purified rat Leydig cell steroidogenesis and adenosine 3',5'-monophosphate production.}, author={Sergio Valenti and Rodrigo Capobianco Guido and Mar{\'i}a de los {\'A}ngeles Giusti and Guido Giordano}, journal={Endocrinology}, year={1995}, volume={136 12}, pages={5357-62} }