In vitro activity of pyronaridine against field isolates and reference clones of Plasmodium falciparum.

@article{Childs1988InVA,
  title={In vitro activity of pyronaridine against field isolates and reference clones of Plasmodium falciparum.},
  author={George E Childs and B H{\"a}usler and Wilbur K. Milhous and C Chen and Theera Wimonwattrawatee and N Pooyindee and Ellen F Boudreau},
  journal={The American journal of tropical medicine and hygiene},
  year={1988},
  volume={38 1},
  pages={24-9}
}
Pyronaridine, a 9-substituted 1-aza-acridine, was assayed for in vitro activity against clinical and field isolates as well as characterized clones of Plasmodium falciparum. The in vitro antimalarial activity of pyronaridine was compared to activities of standard antimalarials against multidrug-resistant isolates of P. falciparum from eastern and northern Thailand using an assay based on the inhibition of schizont maturation. Isolates from eastern Thailand (n = 30) were susceptible to… CONTINUE READING

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