In vitro activity of protegrin-1 and beta-defensin-1, alone and in combination with isoniazid, against Mycobacterium tuberculosis.

@article{Fattorini2004InVA,
  title={In vitro activity of protegrin-1 and beta-defensin-1, alone and in combination with isoniazid, against Mycobacterium tuberculosis.},
  author={Lanfranco 7 Fattorini and Renato Gennaro and Margherita Zanetti and Dejiang Tan and Lara Brunori and Federico Giannoni and Manuela Pardini and G. Orefici},
  journal={Peptides},
  year={2004},
  volume={25 7},
  pages={1075-7}
}
The antimicrobial peptide protegrin-1 (PG-1) inhibited the growth in vitro of drug-susceptible and multidrug-resistant Mycobacterium tuberculosis; a lower activity was shown by human beta-defensin-1 (HBD-1) against both strains. The combination of PG-1 or HBD-1 with isoniazid significantly reduced M. tuberculosis growth in comparison with the peptides or isoniazid alone.