In vitro activity of new artemisinin derivatives against Plasmodium falciparum clinical isolates from Gabon.

@article{Held2011InVA,
  title={In vitro activity of new artemisinin derivatives against Plasmodium falciparum clinical isolates from Gabon.},
  author={Jana Held and Shahid A Soomro and Peter Gottfried Kremsner and Frans Jansen and Benjamin Mordm{\"u}ller},
  journal={International journal of antimicrobial agents},
  year={2011},
  volume={37 5},
  pages={485-8}
}
Nowadays, artemisinins are the mainstay of malaria treatment, but initial indications of resistance against clinically used derivatives are present. In this study, ten new artemisinin derivatives were tested in vitro against Plasmodium falciparum laboratory strains as well as clinical isolates from Gabon. All derivatives were highly active, with 50% inhibitory concentrations (IC(50) values) <13 nM in the clinical isolates. The activity of one fluoro-containing derivative did not correlate with… CONTINUE READING