In-vitro activity of imipenem combined with beta-lactam antibiotics for methicillin-resistant Staphylococcus aureus.

@article{Matsuda1991InvitroAO,
  title={In-vitro activity of imipenem combined with beta-lactam antibiotics for methicillin-resistant Staphylococcus aureus.},
  author={Kenji Matsuda and Y Asahi and Makoto Sanada and Susumu Nakagawa and Nobuo Tanaka and Matsuhisa Inoue},
  journal={The Journal of antimicrobial chemotherapy},
  year={1991},
  volume={27 6},
  pages={809-15}
}
The in-vitro activity of imipenem combined with beta-lactam antibiotics was studied for 25 strains of methicillin and imipenem-resistant Staphylococcus aureus (MRSA) in comparison with that of fosfomycin combined with cefmetazole. Using the chequerboard agar dilution method, strong synergy was seen for all strains for imipenem with cefoperazone, cefotiam, cefpiramide or piperacillin. All fractional inhibitory concentration indices (FIC indices) of these combinations were less than or equal to 0… CONTINUE READING