In vitro activity of daptomycin and vancomycin lock solutions on staphylococcal biofilms in a central venous catheter model.

@article{LaPlante2007InVA,
  title={In vitro activity of daptomycin and vancomycin lock solutions on staphylococcal biofilms in a central venous catheter model.},
  author={Kerry L LaPlante and Leonard A Mermel},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2007},
  volume={22 8},
  pages={2239-46}
}
BACKGROUND Catheter lock solutions are used for prevention and management of catheter-related bloodstream infections. We investigated the activity of daptomycin and vancomycin lock solutions against Staphylococcus aureus and Staphylococcus epidermidis in an in vitro central venous catheter (CVC) model. METHODS Biofilm-producing reference strains of S. aureus and S. epidermidis were evaluated. After 24 h of bacterial growth in a CVC model, daptomycin and vancomycin bactericidal activity… CONTINUE READING

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