In-vitro activity of clinafloxacin, trovafloxacin, and ciprofloxacin.

  title={In-vitro activity of clinafloxacin, trovafloxacin, and ciprofloxacin.},
  author={Michael A. Cohen and Michael D. Huband and Jeffrey W Gage and Shawn Yoder and G E Roland and Stephen J. Gracheck},
  journal={The Journal of antimicrobial chemotherapy},
  volume={40 2},
Clinafloxacin and trovafloxacin are two new fluoroquinolones for which few comparative data are available. When MICs of ciprofloxacin against Gram-positive and Gram-negative nosocomial species were compared, clinafloxacin was the most potent although trovafloxacin was also more active than ciprofloxacin against Staphylococcus aureus and enterococci. All three drugs were bactericidal. Clinafloxacin displayed the lowest frequency of resistance, approximating 10(-11). Development of resistance… CONTINUE READING


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