In vitro activity of amiloride combined with tobramycin against Pseudomonas isolates from patients with cystic fibrosis.

@article{Cohn1988InVA,
  title={In vitro activity of amiloride combined with tobramycin against Pseudomonas isolates from patients with cystic fibrosis.},
  author={Robert C Cohn and Michael R. Jacobs and Stephen C. Aronoff},
  journal={Antimicrobial agents and chemotherapy},
  year={1988},
  volume={32 3},
  pages={395-6}
}
The diuretic amiloride has been under recent investigation as adjunctive therapy for pulmonary disease in children with cystic fibrosis (CF). In preliminary studies, the antimicrobial activity of this agent alone or combined with beta-lactam agents against reference strains of Pseudomonas aeruginosa and P. cepacia was poor; however, amiloride was markedly synergistic with tobramycin against P. cepacia. The purpose of this study was to determine the extent of amiloride-tobramycin synergy against… CONTINUE READING

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