In vitro activities of two antimitotic compounds, pancratistatin and 7-deoxynarciclasine, against Encephalitozoon intestinalis, a microsporidium causing infections in humans.

@article{OuarzaneAmara2001InVA,
  title={In vitro activities of two antimitotic compounds, pancratistatin and 7-deoxynarciclasine, against Encephalitozoon intestinalis, a microsporidium causing infections in humans.},
  author={Meryem Ouarzane-Amara and Jean François Franetich and Dominique Mazier and George R. Pettit and Laurent Meijer and Christian Doerig and Isabelle Desportes-Livage},
  journal={Antimicrobial agents and chemotherapy},
  year={2001},
  volume={45 12},
  pages={3409-15}
}
The antiparasitic effect of a collection of compounds with antimitotic activity has been tested on a mammalian cell line infected with Encephalitozoon intestinalis, a microsporidian causing intestinal and systemic infection in immunocompromised patients. The antiparasitic effect was evaluated by counting the number of parasitophorous vacuoles detected by immunofluorescence. Out of 526 compounds tested, 2 (pancratistatin and 7-deoxynarciclasine) inhibited the infection without affecting the host… CONTINUE READING
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