In vitro activities of novel 4-HPR derivatives on a panel of rhabdoid and other tumor cell lines

@inproceedings{Smith2011InVA,
  title={In vitro activities of novel 4-HPR derivatives on a panel of rhabdoid and other tumor cell lines},
  author={Melissa Edwards Smith and Bhaskar C. Das and Ganjam V. Kalpana},
  booktitle={Cancer Cell International},
  year={2011}
}
Rhabdoid tumors (RTs) are aggressive pediatric malignancies with poor prognosis. N-(4-hydroxy phenyl) retinamide (4-HPR or fenretinide) is a potential chemotherapeutic for RTs with activity correlated to its ability to down-modulate Cyclin D1. Previously, we synthesized novel halogen-substituted and peptidomimetic-derivatives of 4-HPR that retained activity… CONTINUE READING