In vitro activities of ferrochloroquine against 55 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs.

@article{Pradines2002InVA,
  title={In vitro activities of ferrochloroquine against 55 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs.},
  author={Bruno Pradines and Adama Tall and Christophe Rogier and Andr{\'e} Spiegel and Joel Mosnier and Laurence Marrama and Thierry Fusai and Pascal Millet and Emmanuel Panconi and Jean-François Trape and Daniel Parzy},
  journal={Tropical medicine & international health : TM & IH},
  year={2002},
  volume={7 3},
  pages={265-70}
}
The in vitro activities of ferrochloroquine, chloroquine, quinine, mefloquine, halofantrine, amodiaquine, artesunate, atovaquone, cycloguanil and pyrimethamine were evaluated against Plasmodium falciparum isolates from Senegal (Dielmo, Ndiop), using an isotopic micro-drug susceptibility test. The IC50 values for ferrochloroquine ranged from 0.55 to 28.2 nM and the geometric mean IC50 for the 55 isolates was 7.9 nM (95% CI, 6.5-9.7 nM). Ferrochloroquine was 35 times more active than chloroquine… CONTINUE READING