In vitro activation of rat brain protein kinase C by polyenoic very-long-chain fatty acids.

@article{Hardy1994InVA,
  title={In vitro activation of rat brain protein kinase C by polyenoic very-long-chain fatty acids.},
  author={Stephen J. Hardy and Antonio Ferrante and Brenton S. Robinson and David W Johnson and Alfred Poulos and Kathleen J. Clark and Andrew W. Murray},
  journal={Journal of neurochemistry},
  year={1994},
  volume={62 4},
  pages={1546-51}
}
A variety of fatty acids including the cis-polyunsaturated very-long-chain fatty acids (VLCFA) (> 22 carbon atoms) common in retina, spermatozoa, and brain were examined for their ability to activate protein kinase C (PKC) purified from rat brain. Arachidonic [20:4(n-6)], eicosapentaenoic [20:5(n-3)], and docosahexaenoic [22:6(n-3)] acids as well as the… CONTINUE READING