In vitro activated human T lymphocytes very efficiently attach to allogenic multipotent mesenchymal stromal cells and transmigrate under them.

@article{Suv2008InVA,
  title={In vitro activated human T lymphocytes very efficiently attach to allogenic multipotent mesenchymal stromal cells and transmigrate under them.},
  author={Domizio Suv{\`a} and Jakob Robert Passweg and Serge Arnaudeau and Pierre J. Hoffmeyer and Vincent Kindler},
  journal={Journal of cellular physiology},
  year={2008},
  volume={214 3},
  pages={588-94}
}
The regulatory effect of human multipotent mesenchymal stromal cells (MSC) on allogenic T lymphocytes is extremely powerful and of important clinical relevance, but the mechanisms underlying this process are not fully elucidated. We report here that T lymphocytes activated with a sub-mitogenic stimulus such as phytohemaglutinin alone (PHA), or with mitogenic stimuli such as PHA + interleukin-2 (P-IL2), or immobilized anti-CD3 + anti-CD28 mAb (a3-28), tightly bound allogenic MSC and… CONTINUE READING