In vitro absorption and secretory quotients: practical criteria derived from a study of 331 compounds to assess for the impact of P-glycoprotein-mediated efflux on drug candidates.

@article{ThielDemby2004InVA,
  title={In vitro absorption and secretory quotients: practical criteria derived from a study of 331 compounds to assess for the impact of P-glycoprotein-mediated efflux on drug candidates.},
  author={Victoria E Thiel-Demby and Timothy K Tippin and Joan E. Humphreys and Cosette J. Serabjit-Singh and Joseph W. Polli},
  journal={Journal of pharmaceutical sciences},
  year={2004},
  volume={93 10},
  pages={2567-72}
}
The absorptive (AQ) and secretory (SQ) quotients have been proposed as a novel experimental approach to quantify the modulation of intestinal absorption and secretion by P-glycoprotein (Pgp). Because these unidirectional assays inherently assess for the impact of Pgp, conclusions as to whether a compound is a Pgp substrate will be made from the data. Therefore, the objective of this study was to establish the relationship between AQ/SQ and the bidirectional efflux assay and to derive criteria… CONTINUE READING

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