In vitro Transformation of Syrian Hamster Embryo Cells by Diverse Chemical Carcinogens

@article{Dipaolo1972InVT,
  title={In vitro Transformation of Syrian Hamster Embryo Cells by Diverse Chemical Carcinogens},
  author={Joseph A Dipaolo and Richard Lawrence Nelson and Peter J Donovan},
  journal={Nature},
  year={1972},
  volume={235},
  pages={278-280}
}
MOST studies of chemical carcinogenesis in vitro have been limited to chemicals such as the polycyclic carcinogenic hydrocarbons and 4-nitroquinoline-1-oxide and some of its derivatives (reviewed in ref. 1). With these compounds, cells in culture are transformed in vitro, and neoplastic development follows the injection of cells into appropriate hosts. Nitroso compounds such as N-nitrosomethylurea and N-methyl-N-nitrosourethan cause morphological conversion of established cell lines2,3. In one… CONTINUE READING