In vitro QuantiFERON-TB gold antigen specific interleukin-1beta to diagnose TB among HIV-positive subjects.

@article{Prabhavathi2016InVQ,
  title={In vitro QuantiFERON-TB gold antigen specific interleukin-1beta to diagnose TB among HIV-positive subjects.},
  author={Maddineni Prabhavathi and Basirudeen Syed Ahamed Kabeer and Anbarasu Deenadayalan and A. Mani Muthu Raja},
  journal={Tuberculosis},
  year={2016},
  volume={96},
  pages={
          27-30
        }
}
BACKGROUND The recently introduced IFN-γ release assay (IGRA) has been reported to improve the diagnosis of TB. However, IGRA has suboptimal sensitivity to diagnose TB among HIV co-infected subjects. Apart from IFN-γ, the pro inflammatory cytokines such as Interleukin-1beta (IL-1β), Tumor necrosis factor-alpha (TNF-α), IL-2, IL-6, IL-8 and IL-12 are also play a major role in mycobacterial infections. This study aimed to analyze these cytokines for detecting active TB among HIV sero positive… CONTINUE READING
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