In vitro Phase I and Phase II metabolism of the new designer benzodiazepine cloniprazepam using liquid chromatography coupled to quadrupole time‐of‐flight mass spectrometry

@article{Mortel2018InVP,
  title={In vitro Phase I and Phase II metabolism of the new designer benzodiazepine cloniprazepam using liquid chromatography coupled to quadrupole time‐of‐flight mass spectrometry},
  author={Olivier Mortel{\'e} and Philippe Vervliet and Celine Gys and Maarten Degreef and M. Cuykx and K. Maudens and A. Covaci and A. V. van Nuijs and Foon Yin Lai},
  journal={Journal of Pharmaceutical and Biomedical Analysis},
  year={2018},
  volume={153},
  pages={158–167}
}
  • Olivier Mortelé, Philippe Vervliet, +6 authors Foon Yin Lai
  • Published 2018
  • Chemistry, Medicine
  • Journal of Pharmaceutical and Biomedical Analysis
  • HighlightsNine in vitro metabolites of cloniprazepam identified with LC‐QTOF‐MS after incubation with human liver microsomes.Five metabolites proposed as potential analytical targets for cloniprazepam consumption.Clonazepam appeared to be the most prominent metabolite of cloniprazepam. Abstract Designer benzodiazepines have recently emerged as a class of new psychoactive substances. These substances are used in recreational settings and as alternatives to prescription benzodiazepines as self… CONTINUE READING
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