In vitro Penetration and in vivo Distribution of Honokiol into the Intervertebral Disc in Rat.


Honokiol is a potential candidate for the treatment of intervertebral disc (IVD) degeneration. In this study, we develop in vitro and in vivo methods to detect the distribution of honokiol in intervertebral discs using high-performance liquid chromatography. A rat tail disc was used for both experimental models. For the in vivo animal experiment, blood… (More)
DOI: 10.2116/analsci.31.1297

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