In vitro Pb exposure disturbs the balance between Aβ production and elimination: the role of AβPP and neprilysin.

@article{Huang2011InVP,
  title={In vitro Pb exposure disturbs the balance between Aβ production and elimination: the role of AβPP and neprilysin.},
  author={Hui Huang and Syed Waseem Bihaqi and Liuxin Cui and Nasser H. Zawia},
  journal={Neurotoxicology},
  year={2011},
  volume={32 3},
  pages={300-6}
}
Metabolism of β-amyloid peptide (Aβ) is closely associated with the pathology and etiology of Alzheimer's disease (AD). Our previous studies on aging primates and rodents have revealed that early life lead exposure increases the expression of the β-amyloid precursor protein (AβPP), elevates Aβ levels, and promotes neurodegeneration in old age. These effects were attributed to de novo synthetic pathways; however, the impact on Aβ degradation was not explored. Neprilysin (NEP), a rate-limiting… CONTINUE READING