In vitro Induction of Apoptosis in U937 Cells by Perillyl Alcohol with Sensitization by Pentoxifylline: Increased BCL-2 and BAX Protein Expression

@article{GomezContreras2006InVI,
  title={In vitro Induction of Apoptosis in U937 Cells by Perillyl Alcohol with Sensitization by Pentoxifylline: Increased BCL-2 and BAX Protein Expression},
  author={Piedad C. Gomez-Contreras and Georgina Hern{\'a}ndez‐Flores and Pablo Cesar Ortiz‐Lazareno and Susana del Toro-Arreola and Vidal Delgado-Rizo and Jos{\'e} Manuel Lerma-D{\'i}az and Martha Barba-Barajas and Jorge Ramiro Dom{\'i}nguez-Rodr{\'i}guez and A Bravo Cuellar},
  journal={Chemotherapy},
  year={2006},
  volume={52},
  pages={308 - 315}
}
Background: Chemotherapy is effective against a wide variety of tumor cells, although its use is limited by side effects. In vitro experiments and phase I and II trials have shown that phytochemicals such as perillyl alcohol (P-OH) have antitumor effects. Pentoxifylline (PTX), a synthetic methylxanthine used mainly to treat pathologies associated with hematological diseases, sensitizes tumor cells to chemotherapy. The aim of this study was to determine whether PTX amplifies the antitumor… Expand
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