In vitro DNA binding studies of anticancer drug idarubicin using spectroscopic techniques.

@article{Ozluer2014InVD,
  title={In vitro DNA binding studies of anticancer drug idarubicin using spectroscopic techniques.},
  author={Can Ozluer and Hayriye Eda Satana Kara},
  journal={Journal of photochemistry and photobiology. B, Biology},
  year={2014},
  volume={138},
  pages={
          36-42
        }
}
The interaction between idarubicin and double stranded deoxyribonucleic acid (ds-DNA) was investigated by UV-VIS spectrophotometry, fluorescence and Raman spectroscopy techniques. The absorption spectra of idarubicin with ds-DNA showed a slight red shift and hypochromic effect. In the fluorescence experiments, emission peaks were decreased by adding ds-DNA. Using ethidium bromide (ETB) as a fluorescence probe, fluorescence quenching of the emission peak was observed in the ETB-DNA system when… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-7 OF 7 CITATIONS