In vitro DNA-binding profile of transcription factors: methods and new insights.

@article{Wang2011InVD,
  title={In vitro DNA-binding profile of transcription factors: methods and new insights.},
  author={Jinke Wang and Jie Lu and Guangming Gu and Yingxun Liu},
  journal={The Journal of endocrinology},
  year={2011},
  volume={210 1},
  pages={15-27}
}
The DNA-binding specificity of transcription factors (TFs) has broad impacts on cell physiology, cell development and in evolution. However, the DNA-binding specificity of most known TFs still remains unknown. The specificity of a TF protein is determined by its relative affinity to all possible binding sites. In recent years, the development of several in vitro techniques permits high-throughput determination of relative binding affinity of a TF to all possible k bp-long DNA sequences, thus… CONTINUE READING
Highly Cited
This paper has 32 citations. REVIEW CITATIONS

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
10 Extracted Citations
111 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 10 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 111 references

Similar Papers

Loading similar papers…